Comparison of the effects of low-dose rosuvastatin on plasma levels of cholesterol and oxidized low-density lipoprotein in 3 ultracentrifugally separated low-density lipoprotein subfractions
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- 作者：Koichiro Homma ; MD ; PhDa ; b ; homma@keio.jp" class="auth_mail" title="E-mail the corresponding author ; Yasuhiko Homma ; MD ; PhDc ; d ; Hideki Ozawa ; MD ; PhDe ; Yutaka Shiina ; MD ; PhDd ; Takeo Shibata ; MD ; PhDg ; Tadashi Yoshida ; MD ; PhDf ; Kazuhiro Hasegawa ; MD ; PhDb ; Takeshi Kanda ; MD ; PhDb ; Hirobumi Tokuyama ; MD ; PhDb ; Shu Wakino ; MD ; PhDb ; Koichi Hayashi ; MD ; PhDb ; Hiroshi Itoh ; MD ; PhDb ; Shingo Hori ; MD ; PhDa
- 关键词：Rosuvastatin ; LDL subfractions ; Cholesterol ; Oxidized LDL ; Adiponectin ; hs-CRP ; Carotid atherosclerosis
- 刊名：Journal of Clinical Lipidology
- 出版年：2015
- 出版时间：November-December 2015
- 年：2015
- 卷：9
- 期：6
- 页码：751-757
- 全文大小：218 K
文摘
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The small-sized plasma oxidized (ox) low-density lipoprotein (LDL) particles in dense LDL may make them more atherogenic than ox-LDL particles in less-dense LDL.
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The distribution of, and the statin effects, ox-LDL in LDL fractions has not been studied in detail.
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The distributions of cholesterol and ox-LDL in, and the rosuvastatin effects, LDL fractions were studied.
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The distribution of ox-LDL was skewed more toward the denser LDL fractions, compared with cholesterol; rosuvastatin reduced both ox-LDL and cholesterol in all LDL fractions.