Comments on a facile conversion of epoxides to halohydrins with elemental halogen using isonicotinic hydrazide (isoniazide) as a new catalyst—a reinvestigation

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• 作者：Soroka ; Miroslaw ; Goldeman ; Waldemar
• 关键词：Oxiranes ; Ring opening ; Halohydrins ; Bromohydrins ; Hydrazide oxidation by halogens
• 刊名：Journal of Molecular Catalysis. A, Chemical
• 出版年：2005
• 出版时间：March 29, 2005
• 年：2005
• 卷：229
• 期：1-2
• 页码：271-275
• 全文大小：90.2 K

文摘

The reaction of epoxides with bromine or iodine in the presence of isonicotinic hydrazide gives in fact the corresponding 2-halohydrins with reasonable yields, but contrary to the literature statement [H. Sharghi, M.M. Eskandari, R. Ghovami, J. Mol. Catal. A: Chem. 215 (2004) 55–62] the isonicotinic hydrazide is not a catalyst—it is just a stoichiometric reagent which reacts with 2mol of halogene to give quantitatively the nitrogen, and to generate the hydrogen halogenide, which is a real epoxide ring opening compound.