Reinvestigation of the conversion of epoxides into halohydrins with elemental halogen catalysed by thiourea

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• 作者：Soroka ; Miroslaw ; Goldeman ; Waldemar
• 关键词：Oxiranes ; Ring opening ; 2-Halogenoalkanols ; Bromohydrins ; Iodohydrins
• 刊名：Tetrahedron
• 出版年：2005
• 出版时间：April 25, 2005
• 年：2005
• 卷：61
• 期：17
• 页码：4233-4235
• 全文大小：81.8 K

文摘

In contrast to a previous literature report, thiourea is not a catalyst in the ring opening reaction of epoxides by means of bromine or iodine. Instead, thiourea reacts with the halogen to give a complex mixture of products, among them hydrogen halogenides, which are in fact the real epoxide ring opening reactants. The presence of water is crucial in this reaction.