The preparation of N-substituted aminomethylidenebisphosphonates and their tetraalkyl esters via reaction of isonitriles with trialkyl phosphites and hydrogen chloride. Part 1
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- 作者：Waldemar Goldeman ; Artur Kluczy¨½ski ; Miros?aw Soroka
- 关键词：Aminobisphosphonate ; Bisphosphonate ; Bisphosphonic acid ; Aminomethylidenebisphosphonate ; Aminomethylidenebisphosphonic acid ; Isonitrile ; Proton-assisted nucleophilic addition ; Addition reactions
- 刊名：Tetrahedron Letters
- 出版年：2012
- 出版时间：26 September, 2012
- 年：2012
- 卷：53
- 期：39
- 页码：5290-5292
- 全文大小：286 K
文摘
The reaction of isonitriles with trialkyl phosphites in the presence of hydrogen chloride gives tetraalkyl N-substituted aminomethylidenebisphosphonates via N-methylideneaminium (isonitrilium) salts. Hydrolysis or dealkylation of these tetraalkyl esters gives N-substituted aminomethylidenebisphosphonic acids in high yields.