Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex
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- 作者：Nasim F. Mehrabi ; PhDa ; b ; Henry J. Waldvogel ; PhDa ; b ; Lynette J. Tippett ; PhDa ; c ; Virginia M. Hogg ; MDa ; c ; Beth J. Synek ; MDa ; d ; Richard L.M. Faull ; MBChB ; PhD ; DSca ; b ; rlm.faull@auckland.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：Huntington's disease ; Cerebral cortex ; Interneurons ; Pyramidal cells ; Pathology ; Variable symptoms
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：67-74
- 全文大小：1881 K
文摘
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Variable neuronal loss in different cortical regions in Huntington's disease (HD)
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Cortical interneuron loss is linked with cortical pyramidal cell loss in HD.
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Cortical neurodegeneration contributes significantly to neuropathology of HD.
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Variable cortical cell loss correlates with variable symptom profiles in HD.