A comparative study between full-dose and half-dose intravesical immune bacille Calmette-Guérin injection in the management of superficial bladder cancer

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• 作者：Wael Kandeel ; Ashraf Abdelal ; Basheer N. Elmohamady ; ^{bashiralmohamdy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ahmed Sebaey ; Waleed Elshaaer ; Ehab Elbarky ; Osama Abdelwahab
• 关键词：NMIBC ; non-muscle-invasive bladder cancer ; CIS ; carcinoma in situ ; TURBT ; transurethral resection of the bladder tumour
• 刊名：Arab Journal of Urology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：13
• 期：4
• 页码：233-237
• 全文大小：402 K

文摘

To determine whether a half-dose of bacille Calmette–Guérin (BCG) can reduce toxicity without affecting its efficacy in the management of non-muscle-invasive bladder cancer.

Patients and methods

From January 2012 to January 2014, 80 patients with superficial bladder cancer and in the intermediate-risk group were simply randomised to receive two different doses of BCG, i.e., a full dose of 90 mg (group A) or a half-dose of 45 mg (group B). There were no significant differences in clinical and pathological characteristics between the groups. At completion of the study, 40 patients could be evaluated in each group.

Results

All patients were evaluated for a follow-up of 12 months after treatment. There was no significant difference in recurrence rate (15 patients, 38%, in group A and 16, 40%, in group B) in the two groups, and no difference in progression rate of the disease, at eight patients (20%) in each group. There were significant differences between groups A and B in toxicity (grade 1 adverse events, 70% vs. 60%; grade 2, 18% vs. 7.5%, respectively). Grade 3 adverse events were only reported in group A (2.5%).

Conclusion

The half dose of intravesical BCG instillation can reduce the toxicity and side-effects that are associated with the treatment of superficial bladder cancer, without affecting the efficacy of therapy.