Effects of Rispens CVI988 vaccination followed by challenge with Marek’s disease viruses of differing virulence on the replication kinetics and shedding of the vaccine and challenge viruses
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- 作者：Sithara Ralapanawe ; sralapan@myune.edu.au" class="auth_mail" title="E-mail the corresponding author ; Stephen W. Walkden-Brown ; A.F.M. Fakhrul Islam ; Katrin G. Renz
- 关键词：Marek&rsquo ; s disease virus ; Rispens CVI988 ; Differential quantitative PCR ; Evolution of virulence ; Imperfect vaccines ; Co-infection
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：183
- 期：Complete
- 页码：21-29
- 全文大小：1055 K
文摘
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We examined the kinetics of Rispens CVI988 vaccine with two Marek’s disease virus pathotypes of differing virulence.
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Viral load was positively associated with virulence, particularly in PBL, consistent with previous findings.
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Vaccination with Rispens reduced the pathogenic viral load with evidence that the inhibitory effect of vaccination was greatest for the less virulent MDV.
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Challenge with MDV 5 days after vaccination with Rispens can negatively influence the viral load of Rispens in the weeks following challenge.