The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
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- 作者：Rune Busk Damgaard1 ; Jennifer A. Walker1 ; Paola Marco-Casanova1 ; Neil V. Morgan2 ; Hannah L. Titheradge3 ; 4 ; Paul R. Elliott1 ; Duncan McHale5 ; Eamonn R. Maher6 ; erm1000@medschl.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Andrew N.J. McKenzie1 ; anm@mrc-lmb.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; David Komander1 ; 7 ; dk@mrc-lmb.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：166
- 期：5
- 页码：1215-1230.e20
- 全文大小：10921 K
文摘
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Mutation of OTULIN causes OTULIN-related autoinflammatory syndrome (ORAS) in humans
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Anti-TNF treatment reverses inflammation in ORAS patient and OTULIN-deficient mice
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OTULIN deficiency deregulates M1-polyUb signaling and causes sterile inflammation
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Loss of OTULIN has cell-type-specific effects on LUBAC abundance and signaling