ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch
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- 作者：Steven Zhao1 ; 2 ; 7 ; AnnMarie Torres1 ; 2 ; 7 ; Ryan A. Henry5 ; Sophie Trefely1 ; 2 ; 4 ; Martina Wallace6 ; Joyce V. Lee1 ; 2 ; Alessandro Carrer1 ; 2 ; Arjun Sengupta3 ; Sydney L. Campbell1 ; 2 ; Yin-Ming Kuo5 ; Alexander J. Frey4 ; Noah Meurs6 ; John M. Viola1 ; 2 ; Ian A. Blair3 ; Aalim M. Weljie3 ; Christian M. Metallo6 ; Nathaniel W. Snyder4 ; Andrew J. Andrews5 ; Kathryn E. Wellen1 ; 2 ; 8 ; wellenk@exchange.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACLY ; ACSS2 ; acetyl-CoA ; acetate ; acetylation ; fatty acid synthesis ; adipose tissue ; metabolism ; metabolic flexibility
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1037-1052
- 全文大小：4798 K
文摘
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ACSS2 is upregulated upon genetic deletion of Acly in vitro and in vivo
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Acetate sustains viability in Acly-deficient MEFs, but proliferation is impaired
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Low levels of acetate can supply abundant acetyl-CoA in the absence of ACLY
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Acetate partially rescues lipogenesis and histone acetylation in ACLY deficiency