Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction
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- 作者：Ching-On Wong1 ; Michela Palmieri2 ; Jiaxing Li3 ; Dmitry Akhmedov1 ; Yufang Chao1 ; Geoffrey T. Broadhead1 ; Michael X. Zhu1 ; 4 ; Rebecca Berdeaux1 ; 4 ; Catherine A. Collins3 ; Marco Sardiello2 ; Kartik Venkatachalam1 ; 4 ; 5 ; kartik.venkatachalam@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 September 2015
- 年：2015
- 卷：12
- 期：12
- 页码：2009-2020
- 全文大小：3230 K
文摘
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Fly models of lysosomal storage diseases (LSDs) exhibit diminished synaptic growth
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Lysosomal protein degradation and MTORC1 activation promote synaptic growth via JNK
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MTORC1 phosphorylates Wallenda/DLK1, an MAPKKK upstream of JNK in flies and mammals
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ALK inhibition along with high protein diet restores synaptic growth in LSD models