RNF4-Dependent Oncogene Activation by Protein Stabilization
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- 作者：Jane J. Thomas1 ; 9 ; Mona Abed1 ; 9 ; 10 ; Julian Heuberger3 ; 9 ; Rostislav Novak1 ; 2 ; Yaniv Zohar1 ; 2 ; Angela P. Beltran Lopez4 ; Julie S. Trausch-Azar5 ; Ma. Xenia G. Ilagan7 ; David Benhamou1 ; Gunnar Dittmar3 ; Raphael Kopan8 ; Walter Birchmeier3 ; Alan L. Schwartz5 ; 6 ; Amir Orian1 ; 11 ; mdoryan@techunix.technion.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：STUbL ; ubiquitin ; SUMO ; gene regulation ; oncogenes
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：16
- 期：12
- 页码：3388-3400
- 全文大小：4504 K
文摘
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RNF4 stabilizes and enhances the activity of short-lived oncogenes
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Stabilization requires substrate phosphorylation and atypical ubiquitylation
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RNF4 is essential for cancer cell survival
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High RNF4 levels are correlated with reduced survival in epithelial tumors