Small-molecule antioxidants in marine organisms: Antioxidant activity of mycosporine-glycine

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• 作者：Walter C. Dunlap ; Yorihiro Yamamoto
• 关键词：Antioxidants ; Coral trout ; Lissoclinum patella ; Mycosporine-like amino acids ; Mycosporine-glycine ; Oxidative stress ; Palythoa tuberculosa ; Porphyra tenera
• 刊名：Comparative Biochemistry and Physiology, Part B
• 出版年：1995
• 出版时间：September 1995
• 年：1995
• 卷：112
• 期：1
• 页码：105-114
• 全文大小：841 K

文摘

The antioxidant activities of aqueous extracts of tissues from four different marine species containing mycosporine-like amino acids were examined by their peroxyl radical-trapping abilities using the phosphatidylcholine peroxidation inhibition assay. The coral trout (Plectropomus leopardus) lens extract had low oxidation inhibition activity; Porphyra tenera and Lissoclinum patella extracts had moderately strong inhibition activities while the aqueous extract of Palythoa tuberculosa showed the greatest oxidation inhibition activity of the extracts tested; the last two extracts contained mycosporine-glycine. In these sample extracts, mycosporine-glycine was reactive to peroxyl radicals whereas the iminomycosporine-like amino acids, shinorine, porphyra-334, palythine, asterina-330 and palythinol, were oxidatively robust. Purified mycosporine-glycine inhibited peroxyl radical-initiated autoxidation of phosphaditylcholine in a concentration-dependent manner. These results suggest that mycosporine-glycine may function as a biological antioxidant in marine organisms.