A novel MjLRRC1 with 19 LRR motifs was identified in kuruma shrimp. MjLRRC1 was upregulated in stomach by bacterial oral infection. MjLRRC1 bound to bacteria though binding to their cell wall components. MjLRRC1 regulated the expression of AMP genes in stomach. MjLRRC1 participated in bacterial clearance of stomach in shrimp.