The Drosophila F-box protein Slimb controls dSmurf protein turnover to regulate the Hippo pathway

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• 作者：Liangchang Hu¹ ; Ping Wang¹ ; Runan Zhao ; Shanshan Li ; Feng Wang ; Chaojie Li ; Lei Cao ; Shian Wu ; ^{wusa@nankai.edu.cn}
• 关键词：Slimb ; dSmurf ; Ubiquitination ; Hippo signaling
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：317-322
• 全文大小：1465 K
• 卷排序：482

文摘

Slimb associates with dSmurf in Drosophila S2 cells. Slimb controls dSmurf turnover and activity by ubiquitination-mediated protein degradation. Slimb regulates Yki phosphorylation level through promoting dSmurf degradation.