Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer
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- 作者：Yi-Ping Wang1 ; wangyiping@shsmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Zhou1 ; Jian Wang2 ; Xian Huang1 ; Yong Zuo1 ; Tian-Shi Wang1 ; Xue Gao2 ; Ying-Ying Xu2 ; Shao-Wu Zou3 ; Ying-Bin Liu4 ; Jin-Ke Cheng1 ; jkcheng@shsmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qun-Ying Lei2 ; 5 ; qlei@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CARM1 ; MDH1 ; arginine methylation ; pancreatic cancer ; glutamine metabolism ; KRAS ; redox homeostasis ; nicotinamide adenine dinucleotide phosphate ; reactive oxygen species ; mitochondrial respiration
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：673-687
- 全文大小：3971 K
文摘
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Arginine methylation at R248 negatively regulates MDH1 activity
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PRMT4/CARM1 methylates MDH1 at R248 and inhibits its dimerization
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MDH1 methylation suppresses glutamine metabolism of pancreatic cancer
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R248 methylation of MDH1 is downregulated in clinical PDAC samples