Dynamics of an HBV/HCV infection model with intracellular delay and cell proliferation
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- 作者：Fengqin Zhanga ; zhafq@263.net" class="auth_mail" title="E-mail the corresponding author ; Jianquan Lib ; jianq_li@263.net" class="auth_mail" title="E-mail the corresponding author ; Chongwu Zhenga ; chongyang1894@163.com" class="auth_mail" title="E-mail the corresponding author ; Lin Wang ; a ; c ; lwang2@unb.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV/HCV infection ; Intracellular delay ; Stability and bifurcation ; Chaos
- 刊名：Communications in Nonlinear Science and Numerical Simulation
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：42
- 期：Complete
- 页码：464-476
- 全文大小：1521 K
文摘
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An HBV/HCV model with intracellular delay and cell proliferation is analyzed.
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Pontryagin’s method is employed to derive sharp conditions ensuring stability of the infection persistent equilibrium.
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An alternative geometric stability switch criterion is proposed, which is used to show that the intracellular delay can induce stability switches.
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Numerical simulations reveal that the intracellular delay can induce chaos and interesting structure of bifurcation diagram exhibiting persistence bubbles.