Quercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo
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- 作者：Gang Wanga ; wangan139@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun-Jie Wanga ; b ; Xuan-Li Chenb ; Li Dua ; Fei Lia
- 关键词：ATCC ; American Tissue Culture Collection ; BBB ; blood-brain barrier ; CMC ; critical micelle concentration ; DL ; drug loading ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; DPH ; 1 ; 6-diphenyl-1 ; 3 ; 5-hexatriene ; EE ; encapsulation efficiency ; FBS ; fetal bovine serum ; FTIR ; Fourier transform infrared ; HPLC ; high-performance liquid chromatography ; Labrasol ; PEG-8 caprylic/capric glycerides ; LDH ; lactic acid dehydrogenase ; Cmax ; maximum concentration ; MFI ; mean fluorescence intensity
- 刊名：Journal of Controlled Release
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：235
- 期：Complete
- 页码：276-290
- 全文大小：2391 K
文摘
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Quercetin loaded freeze-dried micelles with sustained release profile, increased cellular uptake.
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QUE-FD-NMs efficiently deliver QUE to accumulate in primary tumor tissues.
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QUE-FD-NMs exhibit the better survival rate and the inhibited tumor growth in vivo.
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Freeze-drying micelles loaded with quercetin is a promising drug delivery for glioma therapy.