Development of antibacterial and high light transmittance bulk materials: Incorporation and sustained release of hydrophobic or hydrophilic antibiotics
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- 作者：Bailiang Wang<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>wangbailiang2006@aliyun.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Huihua Liu<sup>bsup> ; Binjun Zhang<sup>asup> ; Yuemei Han<sup>asup> ; Chenghui Shen<sup>bsup> ; Quankui Lin<sup>asup><sup> ; sup><sup>bsup> ; Hao Chen<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>Chenhao823@mail.eye.ac.cn" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Antibacterial ; Poly(dimethyl siloxane) ; Light transmittance ; Sustained release ; Gentamicin
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：483-490
- 全文大小：2992 K
文摘
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A novel bulk material was prepared through combining PDMS with either hydrophobic or hydrophilic antibiotics.
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For both kinds of antibiotics, the optical transmission of the blend films was higher than 90%.
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The blend films demonstrated excellent bactericidal and sufficient biofilm inhibition functions.
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The blend films yielded a significantly low degree of infection in the rabbit subcutaneous S. aureus infection model.