MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3
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- 作者：Yuanhua Liua ; 1 ; Guanghui Liub ; 1 ; Hui Zhanga ; Jing Wanga ; jingwangcc@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pulmonary artery hypertension ; miR-199a-5p ; Smad3 ; Calcium concentration ; Nitric oxide
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：859-866
- 全文大小：2173 K
文摘
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MiR-199a-5p was increased in lung tissues following PAH induction.
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MiR-199a-5p silencing could restore the PAH-induced pathological changes.
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MiR-199a-5p may function as a regulator of PAH by targeting Smad3.