Phenotypic comparison of Caucasian and Asian women with polycystic ovary syndrome: a cross-sectional study

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• 作者：Erica T. Wang ; M.D. ; M.A.S.^a ; ^{erica.wang@cshs.org} ; Chia-Ning Kao ; M.S.^b ; Kanade Shinkai ; M.D. ; Ph.D.^c ; Lauri Pasch ; Ph.D.^d ; Marcelle I. Cedars ; M.D.^b ; Heather G. Huddleston ; M.D.^b
• 关键词：Ethnicity ; hirsutism ; polycystic ovary syndrome
• 刊名：Fertility and Sterility
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：100
• 期：1
• 页码：214-218
• 全文大小：143 K

文摘

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Objective

To determine whether manifestations of polycystic ovary syndrome (PCOS), particularly androgen excess, differ between Caucasian and Asian women in the San Francisco Bay Area.

Design

Cross-sectional study.

Setting

Multidisciplinary PCOS clinic at a tertiary academic center.

Patient(s)

121 Caucasian and 28 Asian women, aged 18-44, examined between 2006 and 2011 with PCOS verified by a reproductive endocrinologist and dermatologist according to the Rotterdam criteria.

Intervention(s)

Transvaginal ultrasounds, comprehensive dermatologic exams, and serum testing.

Main Outcome Measure(s)

Hirsutism defined as a modified Ferriman-Gallwey (mFG) score ¡Ý8, acne, androgenic alopecia, and biochemical hyperandrogenism.

Result(s)

Caucasian and Asian women had a similar prevalence of all measures of androgen excess. Both groups had similar total mFG scores and site-specific mFG scores, except Asian women had a lower site-specific mFG score for the chest. Although Asian women were more likely to use laser hair removal, the results were unchanged when the women with a history of laser hair removal were excluded.

Conclusion(s)

Caucasian and Asian women with PCOS living in the same geographic region had a similar prevalence of hirsutism as well as other markers for androgen excess. Further studies are necessary to evaluate the need for ethnic-specific mFG scores in women with PCOS.