- 作者：Wenhua Zhang ; Shuo Wang ; Cheng Wang ; wangcheng2nd@126.com" class="auth_mail" title="E-mail the corresponding author ; Liping Liu ; Ping Lin ; Fang Li ; Lijia Wu ; Runmei Zou
- 关键词：Twin ; Vasovagal syncope ; Family ; Head-up tilt test
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：221
- 期：Complete
- 页码：194-197
- 全文大小：202 K
Methods
A detailed medical history was taken from four twin pairs of children complaining of dizziness, headache, chest tightness, chest pain, prodromal symptoms of syncope or syncope, meanwhile, these patients were given routine physical examination, 12-lead ECG, echocardiography, Holter ECG, EEG, MRI of the head and other tests to exclude cardio-cerebrovascular and pulmonary diseases, with those with unknown origin for syncope undergoing head-up tilt test (HUTT) and inquiry of detailed family history.
Results
The four pairs of twins with syncope beginning at 7–12 years and induced mostly by standing position (4/5), and positive family history was noted in two pairs. Vasovagal syncope (VVS)-vasoinhibitory response pattern was predominant in HUTT (4/5). The results and the response pattern in HUTT might diversify between two members within same twin pair: one appeared as vasoinhibitory response pattern and one postural orthostatic tachycardia syndrome (POTS) pattern in the first pair, one vasoinhibitory response pattern and one negative response pattern in the second pair, vasoinhibitory response pattern in the third pair and negative response pattern in the fourth pair.
Conclusions
The hereditary factors may play a more important role in younger children with syncope. Environment and psychological factors may induced syncope attack. The results and the response pattern in HUTT are diversified and which might different between two members within twin pair.