Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO
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- 作者：Chuan-Xu Wang ; wangchuanxu1985@163.com" class="auth_mail" title="E-mail the corresponding author ; Ai-Hua Zhao
- 关键词：20E ; 20-Hydroxyecdysone ; S ; Dimethyl sulfoxide ; FBS ; Fetal bovine serum ; H. armigera ; Helicoverpa armigera ; HaEpi ; H. armigera epidermal cell line ; IGF ; Insulin/insulin-like growth factor ; IR ; Insulin receptor ; IRS ; Insulin receptor substrate ; JAK2 ; Janus kinase 2 ; LepR ; Leptin receptor ; LepROT ; Leptin receptor overlapping transcript ; ORF ; Open reading frame ; PI3K ; Phosphoinositide-3 kinase ; PCR ; Polymerase chain reaction ; STAT-3 ; Pignal transducer and activator of transcription 3
- 刊名：Gene
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：587
- 期：1
- 页码：64-69
- 全文大小：830 K
文摘
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LepROT is constitutively expressed during larval development.
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Knockdown of LepROT causes delay of the development of Helicoverpa armigera.
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Knockdown of LepROT results in the upregulation of FoxO and downregulation of PI3K, causes subcellular translocation of FoxO from cytoplasm to nuclei.
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Overexpression of LepROT in the HaEpi cell line inhibits FoxO expression.