Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

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• 作者：Jun Takatoh¹ ; Fan Wang¹ ; ^{fan.wang@duke.edu}
• 刊名：Neuron
• 出版年：2012
• 出版时间：12 April, 2012
• 年：2012
• 卷：74
• 期：1
• 页码：3-5
• 全文大小：195 K

文摘

Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in?developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.