A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin

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• 作者：Wanner ; Jutta ; Tang ; Datong ; McComas ; Casey C. ; Crowley ; Brendan M. ; Jiang ; Wanlong ; Moss ; Jason ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2003
• 出版时间：March 24, 2003
• 年：2003
• 卷：13
• 期：6
• 页码：1169-1173
• 全文大小：173 K

文摘

A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high yield.