The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis
详细信息 查看全文
- 作者：XiaoBing Lia ; MingCai Hub ; WanPing Lia ; Li Gua ; MeiJuan Chena ; HuiHua Dingc ; Kamala Vanarsac ; Yong Duc ; ydu9@central.uh.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Methotrexate ; Reduced folate carrier 1 ; Rheumatoid arthritis ; 80G/A polymorphism ; Efficacy ; Toxicity ; Meta-analysis
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：8-15
- 全文大小：715 K
文摘
- •
The association of RFC1 80G/A polymorphism with MTX efficacy or toxicity in RA patients has been comprehensively analyzed.
- •
All genetic models of RFC1 80G/A have been examined.
- •
RFC1 80G/A gene polymorphism is strongly associated with MTX efficacy in both total population and Asian subgroup analysis.
- •
No association between RFC1 80G/A and MTX related-toxicity was detected in both total population and subgroup analysis.
- •
RFC1 80G/A polymorphism is a potential predictor for MTX response, but not a useful biomarker for MTX-related toxicity.