Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis

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• 作者：Danielle Colledge¹ ; Sally Soppe¹ ; Lilly Yuen ; Lucy Selleck ; Renae Walsh ; Stephen Locarnini ; ^{stephen.locarnini@mh.org.au} ; Nadia Warner
• 关键词：Hepatitis B virus ; Nucleos(t)ide analogue resistance ; Surface stop codons ; Pathogenic variants ; Apoptosis ; Cytopathic variant
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：70-78
• 全文大小：1364 K
• 卷排序：501

文摘

Under normal circumstances, HBV replication is not cytopathic. Premature stop codons in the HBV surface protein can be selected and enriched during nucleos(t)ide analogue therapy. Replication of these variants can be cytopathic to the cell and promote apoptosis. Inadequate antiviral therapy may actually promote disease progression.