FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
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- 作者：Piangkwan Sa-nguanmooa ; b ; Pongpan Tanajaka ; b ; Sasiwan Kerdphooa ; b ; Pattarapong Satjaritanuna ; b ; Xiaojie Wangc ; Guang Liangc ; Xiaokun Lic ; Chao Jiangc ; Wasana Pratchayasakula ; b ; Nipon Chattipakorna ; b ; Siriporn C. Chattipakorna ; d ; scchattipakorn@gmail.com" class="auth_mail" title="E-mail the corresponding author ; siriporn.c@cmu.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：FGF21 ; Obese ; Insulin resistance ; Cognition ; Brain mitochondria
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：86-95
- 全文大小：824 K
文摘
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We investigated the effect of FGF 21 on brain function in obese-insulin resistant rats.
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Obese-insulin resistant rats developed cognitive decline with brain dysfunction.
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Obese-insulin resistant rats had impaired brain FGF21 signaling.
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FGF 21 treatment exerted neuroprotection and prevented cognitive decline in obese-insulin resistant rats.
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The beneficial effects of FGF21 in the brain were mediated by the FGF21 signaling pathway.