Age differences in the risk of diabetes incidence according to body mass index level in Japanese women: BMI and diabetes in women

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• 作者：Yukako Tatsumi ; Yuko Ohno ; Akiko Morimoto ; Yoshio Nishigaki ; Shoichi Mizuno ; Shaw Watanabe
• 关键词：Diabetes ; Age difference ; Women ; Body mass index
• 刊名：Obesity Research Clinical Practice
• 出版年：December, 2013
• 年：2013
• 卷：7
• 期：6
• 页码：e455-e463
• 全文大小：219 K

文摘

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Summary

Objective

To investigate the age differences in the risk of diabetes incidence according to body mass index (BMI).

Methods

For an average of 10.3 years, this study prospectively followed a cohort of 4725 women aged 30-69 years without diabetes at a baseline health check-up conducted between April 1990 and March 1992. Diabetes onset was identified by fasting and random plasma glucose level, HbA_1c or the medical treatment for diabetes by questionnaire. We stratified the subjects according to age (30-39, 40-49, 50-59 and 60-69 years), and calculated the risk of diabetes incidence according to BMI categories (<18.5, 18.5-22.9, 23.0-24.9 and 鈮?5.0 kg/m²) using the Cox proportional hazards model.

Results

During 48,866 person-years of follow-up, 392 subjects developed diabetes. Using the normal group as the reference, the HR (95% CI) for diabetes incidence was elevated in obese women of all ages, ranging from a high of 4.72 (1.79-12.40) for women who were 30-39 years of age, to a low of 1.54 (1.02-2.33) for those who were 50-59 years of age.

Conclusions

The risk of diabetes incidence according to BMI is different among different age groups of Japanese women. Obese is a strong risk factor for diabetes incidence among women of all ages, and especially among young adults.