Inhibition by triptoquinone-A of LPS- and IL-1β-primed induction of no synthase in rat thoracic aorta

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• 作者：Moritoki ; Hideki ; Hisayama ; Tetsuhiro ; Kida ; Kann ; Kondoh ; Wataru ; Inoue ; Shinnichi ; Takaishi ; Yosihisa
• 关键词：triptoquinone-A ; endotoxin (LPS) ; interleukin-1β ; aorta ; ^L-arginine-induced relaxation ; cGMP ; nitrite ; nitric oxide synthase induction
• 刊名：Life Sciences
• 出版年：1996
• 出版时间：June 14, 1996
• 年：1996
• 卷：59
• 期：3
• 页码：PL49-PL54
• 全文大小：443 K

文摘

We investigated the effect of triptoquinone-A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1β (IL-1β). Prophylactic application of TQA selectively prevented LPS-primed initiation of L-arginine (Arg)-induced relaxation, and cGMP formation of rat thoracic, and LPS-stimulated nitrite production by cultured aortic smooth muscle cells, which appear to be mediated by NOS expressed by LPS in vascular smooth muscle. TQA also prevented IL-1β-triggered initiation of Arg-induced relaxation and nitrite accumulation. These results suggest that TQA prevents LPS- or IL-1β-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation.