Combined electroencephalography and magnetoencephalography of interictal spikes in benign rolandic epilepsy of childhood

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• 作者：Ekaterina Pataraia ; Martha Feucht ; Gerald Lindinger ; Susanne Aull-Watschinger ; Christoph Baumgartner
• 关键词：Whole-head magnetoencephalography ; Electroencephalography ; Benign rolandic epilepsy of childhood ; Source localization ; Dipole modeling
• 刊名：Clinical Neurophysiology
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：119
• 期：3
• 页码：635-641
• 全文大小：1145 K

文摘

The neurogenesis and functional organization of the interictal spikes in benign rolandic epilepsy of childhood (BREC) still remains controversial.

Methods

We performed a combined neuroelectric and neuromagnetic study in 24 consecutive patients with BREC using a 143-channel whole-head magnetoencephalography (MEG) system simultaneously with electroencephalography (EEG) recorded from 40 closely spaced scalp-EEG electrodes. Isopotential and isofield maps were calculated over the time window from 250 ms before to 250 ms after the maximum of the negative peak of the spike. We then performed principal component analysis (PCA) and spatio-temporal dipole modeling in order to estimate the number, location and temporal activity of sources.

Results

EEG and MEG spikes were characterized by a stereotypical appearance both within and across patients showing a stable dipolar field distribution over the entire time window. The spikes were generated by a single tangential dipolar source located in the precentral gyrus with the positive pole directed frontally and the negative pole directed centro-temporally.

Conclusions

One source located in the precentral gyrus can adequately explain the spike complex in BREC.

Significance

Simultaneous EEG and MEG provide comprehensive information on functional organization of spikes in BREC.