The key molecular events during Macrobrachium rosenbergii nodavirus (MrNV) infection and replication in Sf9 insect cells
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- 作者：Monsicha Somrita ; Atthaboon Watthammawuta ; Charoonroj Chotwiwatthanakunb ; Wattana Weerachatyanukula ; wattana.wee@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：MrNV ; Virus replication ; Sf9 ; Caveolin-mediated endocytosis pathway
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：1-9
- 全文大小：3892 K
文摘
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The successful infection and replication of MrNV in Sf9 cells should facilitate long-term and in-depth investigation of MrNV infection pathway.
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MrNV internalization favors caveolin (CAV)-mediated pathway which can be halted and reactivated by genistein and okadaic acid.
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Replication of MrNV (at 72 h p.i.) resulted in cytopathic effects (CPE) and multiplication of virion number in the infected cells.