2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice
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- 作者：Robert W. Moorea ; b ; 1 ; robert.moore@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Wayne A. Fritza ; b ; 1 ; 2 ; Wayne.Fritz@covance.com" class="auth_mail" title="E-mail the corresponding author ; Andrew J. Schneidera ; ajschnei@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Tien-Min Lina ; tlin1@facstaff.wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Amanda M. Branama ; b ; 3 ; bran2117@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Stephen Safec ; SSAFE@cvm.tamu.edu" class="auth_mail" title="E-mail the corresponding author ; Richard E. Petersona ; b ; richard.peterson@wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AHT ; atypical hyperplasia of Tag ; AHR ; aryl hydrocarbon receptor ; DIM ; 3 ; 3&prime ; -diindolylmethane ; I3C ; indole-3-carbinol ; IUL ; in utero and lactational ; NEPC ; neuroendocrine prostate carcinoma ; SAHRM ; selective AHR modulator ; Tag ; simian virus 40 large T and small t antigens ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TRAMP ; Transgenic Adenocarcinoma of the Mouse Prostate
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：242-249
- 全文大小：1244 K
文摘
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TRAMP mice model aggressive neuroendocrine prostate carcinomas in men
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In utero/lactational TCDD exposure raised prostate cancer incidence in TRAMP mice.
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TCDD treatment in adulthood lowered prostate cancer incidence in TRAMP mice.
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No significant protection was seen in TRAMP mice given I3C or DIM in adulthood.
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This is the first report that TCDD alters prostate cancer incidence in lab animals.