Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
详细信息 查看全文
- 作者：Yibin Yang1 ; Priscilla Kelly1 ; Arthur L. Shaffer III1 ; Roland Schmitz1 ; Hee Min Yoo1 ; Xinyue Liu1 ; Da Wei Huang1 ; Daniel Webster1 ; Ryan M. Young1 ; Masao Nakagawa1 ; Michele Ceribelli1 ; George W. Wright2 ; Yandan Yang1 ; Hong Zhao1 ; Xin Yu1 ; Weihong Xu1 ; Wing C. Chan3 ; Elaine S. Jaffe4 ; Randy D. Gascoyne5 ; Elias Campo6 ; Andreas Rosenwald7 ; German Ott8 ; Jan Delabie9 ; Lisa Rimsza10 ; Louis M. Staudt1 ; lstaudt@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 April 2016
- 年：2016
- 卷：29
- 期：4
- 页码：494-507
- 全文大小：4877 K
文摘
- •
cIAP1/2 are functional E3 ligases in ABC DLBCL that promote NF-κB activation
- •
cIAP1/2 reside in the CBM complex and deposit K63-polyubiquitin chains there
- •
cIAP1/2 help to recruit LUBAC and IκB kinase to the CBM complex
- •
SMAC mimetics degrade cIAP1/2 and block growth of BCR-dependent ABC DLBCL xenografts