Rosmarinic acid stimulates liver regeneration through the mTOR pathway

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• 作者：Kaihan Lou^a ; ^b ; ¹ ; Min Yang^b ; ¹ ; Erdan Duan^b ; ¹ ; Jiahui Zhao^b ; Cong Yu^b ; Rongping Zhang^d ; Lanchun Zhang^d ; Ming Zhang^b ; Zhicheng Xiao^b ; ^c ; Weiyan Hu^a ; ^b ; ^{huweiyan2004@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhiyong He^b ; ^c ; ^{zhiyonghe2013@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Liver regeneration ; Rosmarinic acid ; mTOR ; Rosemary ; Proliferation ; Partial hepatectomy
• 刊名：Phytomedicine
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：23
• 期：13
• 页码：1574-1582
• 全文大小：3116 K

文摘

Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury.

Hypothesis: We hypothesize that RA stimulates liver regeneration.

Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice.

Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases.

Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH.

Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration.