MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor
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- 作者：Huang-Yu Yang1 ; 2 ; Joseph Barbi1 ; 3 ; Chao-Yi Wu1 ; 4 ; Ying Zheng1 ; 5 ; Paolo D.A. Vignali1 ; Xingmei Wu1 ; 5 ; Jin-Hui Tao1 ; Benjamin V. Park1 ; Shashika Bandara1 ; Lewis Novack1 ; Xuhao Ni1 ; Xiaoping Yang1 ; Kwang-Yu Chang1 ; 6 ; Ren-Chin Wu7 ; Junran Zhang8 ; Chih-Wei Yang2 ; Drew M. Pardoll1 ; Huabin Li5 ; allergyli@163.com" class="auth_mail" title="E-mail the corresponding author ; Fan Pan1 ; fpan1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：45
- 期：1
- 页码：83-93
- 全文大小：2618 K
文摘
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miR-17 targets Eos and other Foxp3 co-regulators via 3′ UTR recognition
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IL-6 drives miR-17 transcription in Treg cells via HIF-1α
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Treg cells lacking miR-17 exhibit increased suppressive function in vitro and in vivo
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miR-17 overexpression in Treg cells exacerbates pathology in a murine colitis model