Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
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- 作者：James Campbell1 ; 9 ; Colm J. Ryan2 ; 9 ; Rachel Brough1 ; Ilirjana Bajrami1 ; Helen N. Pemberton1 ; Irene Y. Chong1 ; 3 ; Sara Costa-Cabral1 ; Jessica Frankum1 ; Aditi Gulati1 ; Harriet Holme1 ; 4 ; Rowan Miller1 ; 4 ; Sophie Postel-Vinay1 ; 5 ; Rumana Rafiq1 ; Wenbin Wei1 ; Chris T. Williamson1 ; David A. Quigley6 ; Joe Tym7 ; Bissan Al-Lazikani7 ; Timothy Fenton4 ; Rachael Natrajan8 ; Sandra J. Strauss4 ; Alan Ashworth1 ; 10 ; alan.ashworth@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Christopher J. Lord1 ; chris.lord@icr.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：14
- 期：10
- 页码：2490-2501
- 全文大小：6761 K
文摘
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Kinome-wide (714 gene) siRNA screens in 117 cell lines from ten cancer histotypes
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Integrating genotype data reveals cancer driver gene dependencies
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Integrating protein interaction data aids the interpretation of genetic dependencies
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Identified dependencies enable prediction of mutant cell line responses to drugs