Effects of tamoxifen on the sex determination gene and the activation of sex reversal in the developing gonad of mice
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- 作者：Mingxi Yua ; yumingxi2003@aliyun.com" class="auth_mail ; Jingyun Wangb ; wangjingyun67@126.com" class="auth_mail ; Wei Liua ; liu_wei@dlut.edu.cn" class="auth_mail ; Junwen Qinc ; junwen@ims.u-tokyo.ac.jp" class="auth_mail ; Quan Zhoud ; tzq@jnu.edu.cn" class="auth_mail ; Yongan Wanga ; Huihui Huangc ; Wenli Chene ; chenwl@scnu.edu.cn" class="auth_mail ; Chao Maf ; macauhello@126.com" class="auth_mail
- 关键词：Tamoxifen ; Sex determination ; Sex reversal ; Endocrine-disrupting chemicals
- 刊名：Toxicology
- 出版年：3 July 2014
- 年：2014
- 卷：321
- 期：Complete
- 页码：89-95
- 全文大小：1584 K
文摘
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Evaluating sex determination pathway by in vivo and in vitro assay.
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Changes in the expression of sex determination genes caused by TAM in mammals.
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TAM affects SOX9 and FOXL2 signaling pathway and results in partial sex reversal.
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The effect of TAM is relevant to the human gender imbalance.