Inhibiting effects of rhynchophylline on zebrafish methamphetamine dependence are associated with amelioration of neurotransmitters content and down-regulation of TH and NR2B expression
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- 作者：Mingjin Jianga ; b ; 1 ; Yifei Chenc ; 1 ; Chan Lia ; Qiuxian Pengd ; Miao Fanga ; Wei Liua ; Qunzhao Kange ; Yingbo Lina ; Ken Kin Lam Yungd ; Zhixian Moa ; cherrymo_smu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Methamphetamine dependence ; Rhynchophylline ; Neurotransmitters ; TH ; NR2B
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 July 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：31-43
- 全文大小：1828 K
文摘
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Rhynchophylline inhibits the formation of METH-induced CPP in zebrafish.
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Rhynchophylline ameliorates the content of dopamine and glutamate in the brains.
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Rhynchophylline down-regulates the expression of TH and NR2B in the brains.
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Rhynchophylline inhibits METH-induced locomotor activity in transgenic larvae.
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Rhynchophylline may be a promising candidate for the treatment of METH addiction.