Lipopolysaccharide promotes tumorigenicity of hepatic progenitor cells by promoting proliferation and blocking normal differentiation

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• 作者：Xiao-Yong Li^a ; ^b ; ¹ ; Xue Yang^b ; ¹ ; Qiu-Dong Zhao^b ; ¹ ; Zhi-Peng Han^b ; Lei Liang^a ; ^b ; Xiao-Rong Pan^a ; ^d ; Jing-Ni Zhu^b ; Rong Li^b ; Meng-Chao Wu^c ; ^{13817669673@163.com} ; Li-Xin Wei^b ; ^{weilixin_smmu@163.com}
• 关键词：Lipopolysaccharide ; HPCs ; Proliferation ; Differentiation
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：35-46
• 全文大小：7351 K
• 卷排序：386

文摘

To validate the correlation between LPS and HPCs. HPCs would be activated by LPS in vivo and vitro. LPS blocked normal differentiation of HPCs. Long-term treatment of LPS on HPCs would promote tumorigenesis.