hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers
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- 作者：Yang Xuana ; b ; 1 ; Jingshu Wanga ; 1 ; Liying Banb ; 1 ; Jian-Jun Luc ; 1 ; Canhui Yib ; Zhenglin Lib ; Wendan Yub ; Mei Lib ; Tingting Xub ; Wenjing Yangb ; Zhipeng Tangb ; Ranran Tangb ; Xiangsheng Xiaoa ; Songshu Mengb ; Yiming Chenb ; Quentin Liua ; b ; Wenlin Huanga ; d ; Wei Guob ; cxn23@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiaonan Cuib ; wei1015@dmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wuguo Denga ; d ; dengwg@sysucc.org.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：hnRNPA2/B1 ; COX-2 ; p300 ; Lung cancer
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：10
- 期：4
- 页码：610-624
- 全文大小：3477 K
文摘
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hnRNPA2/B1 is a novel COX-2 regulator which can specifically bind to COX-2 promoter in NSCLC cells.
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hnRNPA2/B1 activates COX-2 expression, upregulates PGE2 production, and promotes cell growth in NSCLC cells.
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hnRNPA2/B1 expression is positively correlated with COX-2 expression in NSCLC and predicts poor prognosis in lung cancer patients.
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P300 interacts with and acetylates hnRNPA2/B1 protein, thereby promoting COX-2 expression and cell growth in NSCLC cells.