A novel selective and sensitive fluorescent turn-on chemodosimeter based on rhodamine hydrazone for copper ions and its application to bioimaging

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• 作者：Zhihui JiangAuthor Vitae ; Shujuan TianAuthor Vitae ; Changqing WeiAuthor Vitae ; Tingjunhong NiAuthor Vitae ; Yan LiAuthor Vitae ; Li DaiAuthor Vitae ; Dazhi Zhang ; ^{zdzhang_yjhx@smmu.edu.cn}Author Vitae
• 关键词：Chemodosimeter ; Rhodamine B hydrazine ; Cu2+ ; Bioimaging
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2013
• 出版时间：31 July, 2013
• 年：2013
• 卷：184
• 期：Complete
• 页码：106-112
• 全文大小：1977 K

文摘

To develop a selective and sensitive fluorescent turn-on chemodosimeter for copper ions in neutral buffered media, a novel rhodamine hydrazone derivative bearing a piperidinyl group was synthesized. Upon addition of Cu²⁺, the ring-opening process of rhodamine spirolactam was found to result in remarkably enhanced fluorescent and colorimetric labeling, whereas very little fluorescence variations or color changes were observed in the presence of other metal ions (K⁺, Na⁺, Ca²⁺, Mg²⁺, Mn²⁺, Ag⁺, Sn²⁺, Hg²⁺, Pb²⁺, Fe²⁺, Fe³⁺, Zn²⁺, Co²⁺, and Ba²⁺). The detection limit of this newly developed probe was shown to be up to 76 ppb. Importantly, the probe was successfully used for fluorescence imaging in Caco-2 cells.