Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC
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- 作者：Zhuojian Shena ; b ; 1 ; Baishen Chena ; b ; 1 ; Xiangfeng Gang ; Weicheng Huf ; Guangzheng Zhonge ; Haifeng Lic ; Xuan Xiea ; b ; Yeqing Liuc ; Haigang Lic ; Xia Xua ; b ; Zhiquan Huangd ; zhiquanhuang1978@126.com" class="auth_mail" title="E-mail the corresponding author ; Ju Chena ; b ; dydchenju@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NEFL ; NSCLC ; methylation ; NF-κB ; uPA
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：627-634
- 全文大小：2815 K
文摘
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Restoration of NEFL inhibits tumor invasion and metastasis.
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Promoter methylation of NEFL occurred in NSCLC cells.
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Methylation of NEFL correlates with its mRNA and protein downregulation.
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NEFL downregulated uPA via inhibited the NF-κB pathway.
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NEFL was firstly identified as an epigenetic target in NSCLC.