MINDY is a new family of DUBs consisting of FAM63A, FAM63B, FAM188A, and FAM188B
MINDY DUBs are highly selective at cleaving K48-linked polyubiquitin
Catalytic domain of MINDY-1 adopts a distinct fold with no homology to any known DUB
Human MINDY-1 trims ubiquitin chains from the distal end