The combretastatin A-4/oltipraz hybrids were first introduced into CA-4 analogues.
A set of 4,5-diaryl-3H-1,2-dithiole-3-thiones and related compounds were synthesized.
4d and 5c showed potent antiproliferative activities at sub-micromolar IC50 values.
4d inhibited tubulin polymerization and caused cellular arrest in the G2/M phase.
4d was docked with a superimposed docked pose of CA-4.