Data from 1448 patients who had undergone coronary artery bypass grafting with CPB from December 2008 to December 2010 at Singapore's 2 national heart centers were obtained. The perioperative risk factors were analyzed for their associations with postoperative AKI. AKI was defined using the Acute Kidney Injury Network stage 1 criteria.
The incidence of AKI was 27.0% and mean lowest hematocrit during CPB was 24.5% 卤 3.8%. The risk of AKI increased with a decreasing lowest hematocrit during CPB (relative risk, 0.933; 95% confidence interval, 0.899-0.968; P聽<聽.001), in particular with the lowest hematocrit of 鈮?2%. A 23% increased risk of AKI was found for preoperative anemia (relative risk, 1.225; 95% confidence interval, 1.022-1.468; P聽=聽.028). Intraoperative transfusion was related on univariate analysis (P聽<聽.001) but was not independently associated on multivariate analysis (relative risk, 0.961; 95% confidence interval, 0.782-1.180; P聽=聽.702).
The lowest hematocrit and preoperative anemia were potentially modifiable risk factors independently associated with AKI after cardiac surgery in our Asian population. Blood transfusion did not affect the development of AKI in our population.