Doubling Up on Microtubule Stabilizers: Synergistic Functions of Doublecortin-like Kinase and Doublecortin in the Developing Cerebral Cortex

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• 作者：Jill M. Weimer and E.S. Anton
• 刊名：Neuron
• 出版年：2006
• 出版时间：5 January 2006
• 年：2006
• 卷：49
• 期：1
• 页码：3-4
• 全文大小：39 K

文摘

Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables distinct changes in neuronal development in the cerebral cortex. In this issue of Neuron, three related studies on doublecortin-like kinase, a microtubule-associated protein related to doublecortin, by Shu et al., Koizumi et al., and Deuel et al., provide evidence that doublecortin-like kinase is essential for proper neurogenesis, neuronal migration, and axonal wiring.