Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
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- 作者：Gil Ju Seo1 ; Aerin Yang3 ; Brandon Tan1 ; Sungyoon Kim3 ; Qiming Liang1 ; Younho Choi1 ; Weiming Yuan1 ; Pinghui Feng1 ; Hee-Sung Park3 ; Jae U. Jung1 ; 2 ; jaeujung@med.usc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：13
- 期：2
- 页码：440-449
- 全文大小：2307 K
文摘
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Akt-mediated phosphorylation robustly suppresses cGAS enzymatic activity
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Akt-mediated phosphorylation changes cytokine production and HSV-1 replication
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Akt phosphorylation-resistant cGAS enhances IFN-尾 production upon virus infection