Synthesis of Heterocycles Containing Two Cytosine or Two Guanine Base-Pairing Sites. Novel Tectons for Self-Assembly

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• 作者：Petersen ; Paul M. ; Wu ; Weiming ; Fenlon ; Edward E. ; Kim ; Sungho ; Zimmerman ; Steven C.
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：1996
• 出版时间：July, 1996
• 年：1996
• 卷：4
• 期：7
• 页码：1107-1112
• 全文大小：529 K

文摘

The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.