Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts
详细信息 查看全文
- 作者：Junting Chena ; c ; 1 ; Jun Gaob ; 1 ; Weiming Suna ; c ; Lina Lia ; c ; Yuehong Wanga ; c ; Shuzhi Baia ; c ; Xiaoxue Lia ; c ; Rui Wangd ; Lingyun Wud ; Hongzhu Lia ; c ; hongzhuli61@163.com" class="auth_mail" title="E-mail the corresponding author ; Changqing Xua ; c ; xucq45@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AICAR ; 5-aminoimidazole-4-carboxamide riboside ; Akt ; protein kinase ; AMPK ; adenosine 5&prime ; -monophosphate (AMP)-activated protein kinase ; Atg 5 ; autophagy related gene 5 ; CBS ; cystathionine beta-synthase ; CCK-8 ; Cell Counting Kit-8 ; CK ; creatine kinase ; CSE ; cystathionine gamma-lyase ; Cyt c ; cytochrome c ; ; + ; dp/dt and &ndash ; dp/dt ; positive and negative maximum rate of left ventricular pressure development ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; GAPDH ; glyceraldehyde-3-ph
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：220
- 期：Complete
- 页码：681-692
- 全文大小：3542 K
文摘
- •
Ischemic post-conditioning (PC) loses myocardial protective effect in the aged hearts.
- •
Exogenous hydrogen sulfide (H2S) restores cardioprotection of PC in the aged hearts.
- •
Exogenous H2S restores cardioprotection of PC via up-regulation of autophagy in the aged hearts.