Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells
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- 作者：Stephanie Grainger1 ; 8 ; Jenna Richter1 ; 2 ; 8 ; Raquel Espí ; n Palazó ; n1 ; Claire Pouget1 ; Brianna Lonquich1 ; Sara Wirth1 ; Kathrin Sabine Grassme3 ; Wiebke Herzog3 ; 4 ; 5 ; Matthew R. Swift6 ; Brant M. Weinstein7 ; David Traver1 ; 9 ; dtraver@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Karl Willert1 ; kwillert@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hematopoietic stem cells ; HSCs ; hematopoietic stem and progenitor cells ; HSPCs ; Wnt ; Wnt9a ; Myc ; proliferation ; aorta
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1595-1606
- 全文大小：3311 K
文摘
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An early Wnt cue directs later HSPC proliferation, prior to secondary amplification
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Wnt9a is uniquely required for early HSPC amplification
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Myc is downstream of the Wnt cue necessary for proliferation